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Its pro-angiogenic mechanism raises a theoretical concern about tumor growth promotion, described in the literature as "a double-edged sword." WADA has banned it as an unapproved substance

In the WHI estrogen-alone substudy, a statistically significant increased risk of stroke was reported in women 50 to 79 years of age receiving estrogen-alone compared to women in the same age group receiving placebo (45 vs

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